PDP1-INA Fusion FISH Probe
The PDP1-INA Fusion FISH Probe is used to confirm a fusion of the PDP1 and INA genes. The fusion of the PDP1 and INA genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDP1-INA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-RERE | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-REOR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-REGO | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-REGR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-REAQ | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-ORRE | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-OROR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-ORGO | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GORE | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GOOR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GOGO | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GOGR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GRRE | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GROR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GRGO | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GRGR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-AQRE | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-AQOR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-AQGO | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-AQGR | 20 (40 μL) | 200 μL |
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| PDP1-INA-20-AQAQ | 20 (40 μL) | 200 μL |
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INA Gene Summary
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
Gene Name: Internexin Neuronal Intermediate Filament Protein Alpha
Chromosome: CHR10: 105036919 -105050108
Locus: 10q24.33
PDP1 Gene Summary
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Gene Name: Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1
Chromosome: CHR8: 94929082 -94938296
Locus: 8q22.1
Gene Diseases
The PDP1 INA Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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