PDLIM3-SORBS2 Fusion FISH Probe
The PDLIM3-SORBS2 Fusion FISH Probe is used to confirm a fusion of the PDLIM3 and SORBS2 genes. The fusion of the PDLIM3 and SORBS2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDLIM3-SORBS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-RERE | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-REOR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-REGO | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-REGR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-REAQ | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-ORRE | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-OROR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-ORGO | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GORE | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GOOR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GOGO | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GOGR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GRRE | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GROR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GRGO | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GRGR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-AQRE | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-AQOR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-AQGO | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-AQGR | 20 (40 μL) | 200 μL |
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| PDLIM3-SORBS2-20-AQAQ | 20 (40 μL) | 200 μL |
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SORBS2 Gene Summary
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Sorbin And SH3 Domain Containing 2
Chromosome: CHR4: 186506597 -186877870
Locus: 4q35.1
PDLIM3 Gene Summary
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]
Gene Name: PDZ And LIM Domain 3
Chromosome: CHR4: 186421814 -186456712
Locus: 4q35.1
Gene Diseases
The PDLIM3 SORBS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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