PDK3-NAV3 Fusion FISH Probe
The PDK3-NAV3 Fusion FISH Probe is used to confirm a fusion of the PDK3 and NAV3 genes. The fusion of the PDK3 and NAV3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDK3-NAV3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-RERE | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-REOR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-REGO | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-REGR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-REAQ | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-ORRE | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-OROR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-ORGO | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GORE | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GOOR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GOGO | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GOGR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GRRE | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GROR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GRGO | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GRGR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-AQRE | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-AQOR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-AQGO | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-AQGR | 20 (40 μL) | 200 μL |
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| PDK3-NAV3-20-AQAQ | 20 (40 μL) | 200 μL |
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PDK3 Gene Summary
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Name: Pyruvate Dehydrogenase Kinase 3
Chromosome: CHRX: 24483343 -24568583
Locus: Xp22.11
NAV3 Gene Summary
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]
Gene Name: Neuron Navigator 3
Chromosome: CHR12: 78225068 -78606790
Locus: 12q21.2
Gene Diseases
The PDK3 NAV3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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