PDK3-CADPS Fusion FISH Probe
The PDK3-CADPS Fusion FISH Probe is used to confirm a fusion of the PDK3 and CADPS genes. The fusion of the PDK3 and CADPS genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDK3-CADPS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-RERE | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-REOR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-REGO | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-REGR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-REAQ | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-ORRE | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-OROR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-ORGO | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GORE | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GOOR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GOGO | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GOGR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GRRE | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GROR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GRGO | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GRGR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-AQRE | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-AQOR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-AQGO | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-AQGR | 20 (40 μL) | 200 μL |
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| PDK3-CADPS-20-AQAQ | 20 (40 μL) | 200 μL |
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PDK3 Gene Summary
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Name: Pyruvate Dehydrogenase Kinase 3
Chromosome: CHRX: 24483343 -24568583
Locus: Xp22.11
CADPS Gene Summary
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Gene Name: Calcium Dependent Secretion Activator
Chromosome: CHR3: 62384020 -62861064
Locus: 3p14.2
Gene Diseases
The PDK3 CADPS Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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