PDIA5-DIRC2 Fusion FISH Probe
The PDIA5-DIRC2 Fusion FISH Probe is used to confirm a fusion of the PDIA5 and DIRC2 genes. The fusion of the PDIA5 and DIRC2 genes has been associated with Ovarian Serous Cystadenocarcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDIA5-DIRC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-RERE | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-REOR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-REGO | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-REGR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-REAQ | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-ORRE | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-OROR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-ORGO | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GORE | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GOOR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GOGO | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GOGR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GRRE | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GROR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GRGO | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GRGR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-AQRE | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-AQOR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-AQGO | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-AQGR | 20 (40 μL) | 200 μL |
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| PDIA5-DIRC2-20-AQAQ | 20 (40 μL) | 200 μL |
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PDIA5 Gene Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]
Gene Name: Protein Disulfide Isomerase Family A Member 5
Chromosome: CHR3: 122785855 -122880953
Locus: 3q21.1
DIRC2 Gene Summary
This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Disrupted In Renal Carcinoma 2
Chromosome: CHR3: 122513900 -122599986
Locus: 3q21.1
Gene Diseases
The PDIA5 DIRC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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