PDIA4-CBX5 Fusion FISH Probe
The PDIA4-CBX5 Fusion FISH Probe is used to confirm a fusion of the PDIA4 and CBX5 genes. The fusion of the PDIA4 and CBX5 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDIA4-CBX5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-RERE | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-REOR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-REGO | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-REGR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-REAQ | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-ORRE | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-OROR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-ORGO | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GORE | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GOOR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GOGO | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GOGR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GRRE | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GROR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GRGO | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GRGR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-AQRE | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-AQOR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-AQGO | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-AQGR | 20 (40 μL) | 200 μL |
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| PDIA4-CBX5-20-AQAQ | 20 (40 μL) | 200 μL |
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PDIA4 Gene Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]
Gene Name: Protein Disulfide Isomerase Family A Member 4
Chromosome: CHR7: 148700153 -148725782
Locus: 7q36.1
CBX5 Gene Summary
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Chromobox 5
Chromosome: CHR12: 54624730 -54673915
Locus: 12q13.13
Gene Diseases
The PDIA4 CBX5 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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