PDHX-EHF Fusion FISH Probe
The PDHX-EHF Fusion FISH Probe is used to confirm a fusion of the PDHX and EHF genes. The fusion of the PDHX and EHF genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDHX-EHF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-RERE | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-REOR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-REGO | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-REGR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-REAQ | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-ORRE | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-OROR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-ORGO | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GORE | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GOOR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GOGO | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GOGR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GRRE | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GROR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GRGO | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GRGR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-AQRE | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-AQOR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-AQGO | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-AQGR | 20 (40 μL) | 200 μL |
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| PDHX-EHF-20-AQAQ | 20 (40 μL) | 200 μL |
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PDHX Gene Summary
The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: Pyruvate Dehydrogenase Complex Component X
Chromosome: CHR11: 34937676 -35017675
Locus: 11p13
EHF Gene Summary
This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Name: ETS Homologous Factor
Chromosome: CHR11: 34642587 -34684834
Locus: 11p13
Gene Diseases
The PDHX EHF Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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