PDHX-CAT Fusion FISH Probe
The PDHX-CAT Fusion FISH Probe is used to confirm a fusion of the PDHX and CAT genes. The fusion of the PDHX and CAT genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDHX-CAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-RERE | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-REOR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-REGO | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-REGR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-REAQ | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-ORRE | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-OROR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-ORGO | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GORE | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GOOR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GOGO | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GOGR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GRRE | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GROR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GRGO | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GRGR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-AQRE | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-AQOR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-AQGO | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-AQGR | 20 (40 μL) | 200 μL |
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| PDHX-CAT-20-AQAQ | 20 (40 μL) | 200 μL |
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CAT Gene Summary
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Gene Name: Catalase
Chromosome: CHR11: 34460471 -34493607
Locus: 11p13
PDHX Gene Summary
The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: Pyruvate Dehydrogenase Complex Component X
Chromosome: CHR11: 34937676 -35017675
Locus: 11p13
Gene Diseases
The PDHX CAT Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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