PDHB-CACNA2D3 Fusion FISH Probe
The PDHB-CACNA2D3 Fusion FISH Probe is used to confirm a fusion of the PDHB and CACNA2D3 genes. The fusion of the PDHB and CACNA2D3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDHB-CACNA2D3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-RERE | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-REOR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-REGO | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-REGR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-REAQ | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-ORRE | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-OROR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-ORGO | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GORE | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GOOR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GOGO | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GOGR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GRRE | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GROR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GRGO | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GRGR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-AQRE | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-AQOR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-AQGO | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-AQGR | 20 (40 μL) | 200 μL |
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| PDHB-CACNA2D3-20-AQAQ | 20 (40 μL) | 200 μL |
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PDHB Gene Summary
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Pyruvate Dehydrogenase E1 Beta Subunit
Chromosome: CHR3: 58413356 -58419579
Locus: 3p14.3
CACNA2D3 Gene Summary
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 3
Chromosome: CHR3: 54156692 -55108584
Locus: 3p21.1-p14.3
Gene Diseases
The PDHB CACNA2D3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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