PDGFRL-VPS37A Fusion FISH Probe
The PDGFRL-VPS37A Fusion FISH Probe is used to confirm a fusion of the PDGFRL and VPS37A genes. The fusion of the PDGFRL and VPS37A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDGFRL-VPS37A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-RERE | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-REOR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-REGO | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-REGR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-REAQ | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-ORRE | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-OROR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-ORGO | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GORE | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GOOR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GOGO | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GOGR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GRRE | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GROR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GRGO | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GRGR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-AQRE | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-AQOR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-AQGO | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-AQGR | 20 (40 μL) | 200 μL |
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| PDGFRL-VPS37A-20-AQAQ | 20 (40 μL) | 200 μL |
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PDGFRL Gene Summary
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]
Gene Name: Platelet Derived Growth Factor Receptor Like
Chromosome: CHR8: 17433941 -17500642
Locus: 8p22
VPS37A Gene Summary
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: VPS37A, ESCRT-I Subunit
Chromosome: CHR8: 17104400 -17155533
Locus: 8p22
Gene Diseases
The PDGFRL VPS37A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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