PDGFRB-FAR1 Fusion FISH Probe
The PDGFRB-FAR1 Fusion FISH Probe is used to confirm a fusion of the PDGFRB and FAR1 genes. The fusion of the PDGFRB and FAR1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDGFRB-FAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-RERE | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-REOR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-REGO | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-REGR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-OROR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GORE | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GROR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| PDGFRB-FAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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PDGFRB Gene Summary
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]
Gene Name: Platelet Derived Growth Factor Receptor Beta
Chromosome: CHR5: 149493401 -149535422
Locus: 5q32
FAR1 Gene Summary
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Gene Name: Fatty Acyl-CoA Reductase 1
Chromosome: CHR11: 13690205 -13753893
Locus: 11p15.3
Gene Diseases
The PDGFRB FAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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