PDGFRA-USP8 Fusion FISH Probe
The PDGFRA-USP8 Fusion FISH Probe is used to confirm a fusion of the PDGFRA and USP8 genes. The fusion of the PDGFRA and USP8 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDGFRA-USP8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-RERE | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-REOR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-REGO | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-REGR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-REAQ | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-ORRE | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-OROR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-ORGO | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GORE | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GOOR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GOGO | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GOGR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GRRE | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GROR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GRGO | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GRGR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-AQRE | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-AQOR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-AQGO | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-AQGR | 20 (40 μL) | 200 μL |
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| PDGFRA-USP8-20-AQAQ | 20 (40 μL) | 200 μL |
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PDGFRA Gene Summary
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Gene Name: Platelet Derived Growth Factor Receptor Alpha
Chromosome: CHR4: 55095263 -55164412
Locus: 4q12
USP8 Gene Summary
This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Ubiquitin Specific Peptidase 8
Chromosome: CHR15: 50716578 -50793277
Locus: 15q21.2
Gene Diseases
The PDGFRA USP8 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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