PDGFB-DGCR2 Fusion FISH Probe
The PDGFB-DGCR2 Fusion FISH Probe is used to confirm a fusion of the PDGFB and DGCR2 genes. The fusion of the PDGFB and DGCR2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDGFB-DGCR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-RERE | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-REOR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-REGO | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-REGR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-REAQ | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-ORRE | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-OROR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-ORGO | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GORE | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GOOR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GOGO | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GOGR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GRRE | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GROR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GRGO | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GRGR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-AQRE | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-AQOR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-AQGO | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-AQGR | 20 (40 μL) | 200 μL |
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| PDGFB-DGCR2-20-AQAQ | 20 (40 μL) | 200 μL |
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PDGFB Gene Summary
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Platelet Derived Growth Factor Subunit B
Chromosome: CHR22: 39619684 -39640957
Locus: 22q13.1
DGCR2 Gene Summary
Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: DiGeorge Syndrome Critical Region Gene 2
Chromosome: CHR22: 19023794 -19109967
Locus: 22q11.21
Gene Diseases
The PDGFB DGCR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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