PDE8A-BNC1 Fusion FISH Probe
The PDE8A-BNC1 Fusion FISH Probe is used to confirm a fusion of the PDE8A and BNC1 genes. The fusion of the PDE8A and BNC1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE8A-BNC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-RERE | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-REOR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-REGO | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-REGR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-OROR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GORE | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GROR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE8A-BNC1-20-AQAQ | 20 (40 μL) | 200 μL |
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BNC1 Gene Summary
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014]
Gene Name: Basonuclin 1
Chromosome: CHR15: 83924654 -83953468
Locus: 15q25.2
PDE8A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Name: Phosphodiesterase 8A
Chromosome: CHR15: 85523743 -85682376
Locus: 15q25.3
Gene Diseases
The PDE8A BNC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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