PDE7A-COPS5 Fusion FISH Probe
The PDE7A-COPS5 Fusion FISH Probe is used to confirm a fusion of the PDE7A and COPS5 genes. The fusion of the PDE7A and COPS5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE7A-COPS5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-RERE | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-REOR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-REGO | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-REGR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-OROR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GORE | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GROR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE7A-COPS5-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE7A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Phosphodiesterase 7A
Chromosome: CHR8: 66626568 -66753969
Locus: 8q13.1
COPS5 Gene Summary
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
Gene Name: COP9 Signalosome Subunit 5
Chromosome: CHR8: 67955314 -67974562
Locus: 8q13.1
Gene Diseases
The PDE7A COPS5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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