PDE4D-RGS7BP Fusion FISH Probe
The PDE4D-RGS7BP Fusion FISH Probe is used to confirm a fusion of the PDE4D and RGS7BP genes. The fusion of the PDE4D and RGS7BP genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE4D-RGS7BP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-RERE | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-REOR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-REGO | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-REGR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-OROR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GORE | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GROR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE4D-RGS7BP-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE4D Gene Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Gene Name: Phosphodiesterase 4D
Chromosome: CHR5: 58264865 -59783925
Locus: 5q11.2-q12.1
RGS7BP Gene Summary
This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Gene Name: Regulator Of G Protein Signaling 7 Binding Protein
Chromosome: CHR5: 63802451 -63908121
Locus: 5q12.3
Gene Diseases
The PDE4D RGS7BP Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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