PDE4D-INTS10 Fusion FISH Probe
The PDE4D-INTS10 Fusion FISH Probe is used to confirm a fusion of the PDE4D and INTS10 genes. The fusion of the PDE4D and INTS10 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE4D-INTS10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-RERE | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-REOR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-REGO | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-REGR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-OROR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GORE | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GROR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE4D-INTS10-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE4D Gene Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Gene Name: Phosphodiesterase 4D
Chromosome: CHR5: 58264865 -59783925
Locus: 5q11.2-q12.1
INTS10 Gene Summary
INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Name: Integrator Complex Subunit 10
Chromosome: CHR8: 19674917 -19709586
Locus: 8p21.3
Gene Diseases
The PDE4D INTS10 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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