PDE4D-ERCC8 Fusion FISH Probe
The PDE4D-ERCC8 Fusion FISH Probe is used to confirm a fusion of the PDE4D and ERCC8 genes. The fusion of the PDE4D and ERCC8 genes has been associated with Breast Invasive Carcinoma, Stomach Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE4D-ERCC8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-RERE | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-REOR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-REGO | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-REGR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-OROR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GORE | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GROR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE4D-ERCC8-20-AQAQ | 20 (40 μL) | 200 μL |
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ERCC8 Gene Summary
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Gene Name: ERCC Excision Repair 8, CSA Ubiquitin Ligase Complex Subunit
Chromosome: CHR5: 60169658 -60240905
Locus: 5q12.1
PDE4D Gene Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Gene Name: Phosphodiesterase 4D
Chromosome: CHR5: 58264865 -59783925
Locus: 5q11.2-q12.1
Gene Diseases
The PDE4D ERCC8 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Stomach Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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