PDE4D-EFNA5 Fusion FISH Probe
The PDE4D-EFNA5 Fusion FISH Probe is used to confirm a fusion of the PDE4D and EFNA5 genes. The fusion of the PDE4D and EFNA5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE4D-EFNA5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-RERE | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-REOR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-REGO | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-REGR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-OROR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GORE | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GROR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE4D-EFNA5-20-AQAQ | 20 (40 μL) | 200 μL |
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EFNA5 Gene Summary
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Gene Name: Ephrin A5
Chromosome: CHR5: 106712589 -107006596
Locus: 5q21.3
PDE4D Gene Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Gene Name: Phosphodiesterase 4D
Chromosome: CHR5: 58264865 -59783925
Locus: 5q11.2-q12.1
Gene Diseases
The PDE4D EFNA5 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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