PDE4B-JAK1 Fusion FISH Probe
The PDE4B-JAK1 Fusion FISH Probe is used to confirm a fusion of the PDE4B and JAK1 genes. The fusion of the PDE4B and JAK1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE4B-JAK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-RERE | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-REOR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-REGO | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-REGR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-OROR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GORE | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GROR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE4B-JAK1-20-AQAQ | 20 (40 μL) | 200 μL |
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JAK1 Gene Summary
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: Janus Kinase 1
Chromosome: CHR1: 65298905 -65432187
Locus: 1p31.3
PDE4B Gene Summary
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Name: Phosphodiesterase 4B
Chromosome: CHR1: 66258192 -66840262
Locus: 1p31.3
Gene Diseases
The PDE4B JAK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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