PDE4A-S1PR5 Fusion FISH Probe
The PDE4A-S1PR5 Fusion FISH Probe is used to confirm a fusion of the PDE4A and S1PR5 genes. The fusion of the PDE4A and S1PR5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE4A-S1PR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-RERE | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-REOR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-REGO | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-REGR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-OROR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GORE | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GROR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE4A-S1PR5-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE4A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Name: Phosphodiesterase 4A
Chromosome: CHR19: 10527448 -10580307
Locus: 19p13.2
S1PR5 Gene Summary
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Gene Name: Sphingosine-1-phosphate Receptor 5
Chromosome: CHR19: 10623417 -10628668
Locus: 19p13.2
Gene Diseases
The PDE4A S1PR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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