PDE3A-CCT2 Fusion FISH Probe
The PDE3A-CCT2 Fusion FISH Probe is used to confirm a fusion of the PDE3A and CCT2 genes. The fusion of the PDE3A and CCT2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE3A-CCT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-RERE | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-REOR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-REGO | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-REGR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-OROR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GORE | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GROR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE3A-CCT2-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE3A Gene Summary
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Phosphodiesterase 3A
Chromosome: CHR12: 20522196 -20833881
Locus: 12p12.2
CCT2 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Name: Chaperonin Containing TCP1 Subunit 2
Chromosome: CHR12: 69979207 -69995357
Locus: 12q15
Gene Diseases
The PDE3A CCT2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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