PDE10A-POLB Fusion FISH Probe
The PDE10A-POLB Fusion FISH Probe is used to confirm a fusion of the PDE10A and POLB genes. The fusion of the PDE10A and POLB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE10A-POLB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-RERE | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-REOR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-REGO | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-REGR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-OROR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GORE | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GROR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE10A-POLB-20-AQAQ | 20 (40 μL) | 200 μL |
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POLB Gene Summary
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Gene Name: DNA Polymerase Beta
Chromosome: CHR8: 42195972 -42229331
Locus: 8p11.21
PDE10A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Phosphodiesterase 10A
Chromosome: CHR6: 165740777 -166075584
Locus: 6q27
Gene Diseases
The PDE10A POLB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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