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PDE10A-DDX23 Fusion FISH Probe

The PDE10A-DDX23 Fusion FISH Probe is used to confirm a fusion of the PDE10A and DDX23 genes. The fusion of the PDE10A and DDX23 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PDE10A-DDX23-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PDE10A-DDX23-20-RERE 20 (40 μL) 200 μL
PDE10A-DDX23-20-REOR 20 (40 μL) 200 μL
PDE10A-DDX23-20-REGO 20 (40 μL) 200 μL
PDE10A-DDX23-20-REGR 20 (40 μL) 200 μL
PDE10A-DDX23-20-REAQ 20 (40 μL) 200 μL
PDE10A-DDX23-20-ORRE 20 (40 μL) 200 μL
PDE10A-DDX23-20-OROR 20 (40 μL) 200 μL
PDE10A-DDX23-20-ORGO 20 (40 μL) 200 μL
PDE10A-DDX23-20-ORAQ 20 (40 μL) 200 μL
PDE10A-DDX23-20-GORE 20 (40 μL) 200 μL
PDE10A-DDX23-20-GOOR 20 (40 μL) 200 μL
PDE10A-DDX23-20-GOGO 20 (40 μL) 200 μL
PDE10A-DDX23-20-GOGR 20 (40 μL) 200 μL
PDE10A-DDX23-20-GOAQ 20 (40 μL) 200 μL
PDE10A-DDX23-20-GRRE 20 (40 μL) 200 μL
PDE10A-DDX23-20-GROR 20 (40 μL) 200 μL
PDE10A-DDX23-20-GRGO 20 (40 μL) 200 μL
PDE10A-DDX23-20-GRGR 20 (40 μL) 200 μL
PDE10A-DDX23-20-GRAQ 20 (40 μL) 200 μL
PDE10A-DDX23-20-AQRE 20 (40 μL) 200 μL
PDE10A-DDX23-20-AQOR 20 (40 μL) 200 μL
PDE10A-DDX23-20-AQGO 20 (40 μL) 200 μL
PDE10A-DDX23-20-AQGR 20 (40 μL) 200 μL
PDE10A-DDX23-20-AQAQ 20 (40 μL) 200 μL

DDX23 Gene Summary

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Name: DEAD-box Helicase 23

Chromosome: CHR12: 49223538 -49245957

Locus: 12q13.12

PDE10A Gene Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

Gene Name: Phosphodiesterase 10A

Chromosome: CHR6: 165740777 -166075584

Locus: 6q27

Gene Diseases

The PDE10A DDX23 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.