PDCD6-SDHA Fusion FISH Probe
The PDCD6-SDHA Fusion FISH Probe is used to confirm a fusion of the PDCD6 and SDHA genes. The fusion of the PDCD6 and SDHA genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDCD6-SDHA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-RERE | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-REOR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-REGO | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-REGR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-REAQ | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-ORRE | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-OROR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-ORGO | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GORE | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GOOR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GOGO | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GOGR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GRRE | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GROR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GRGO | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GRGR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-AQRE | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-AQOR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-AQGO | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-AQGR | 20 (40 μL) | 200 μL |
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| PDCD6-SDHA-20-AQAQ | 20 (40 μL) | 200 μL |
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SDHA Gene Summary
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Name: Succinate Dehydrogenase Complex Flavoprotein Subunit A
Chromosome: CHR5: 218355 -256814
Locus: 5p15.33
PDCD6 Gene Summary
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]
Gene Name: Programmed Cell Death 6
Chromosome: CHR5: 271735 -315089
Locus: 5p15.33
Gene Diseases
The PDCD6 SDHA Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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