PCYT1B-SIAH1 Fusion FISH Probe
The PCYT1B-SIAH1 Fusion FISH Probe is used to confirm a fusion of the PCYT1B and SIAH1 genes. The fusion of the PCYT1B and SIAH1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCYT1B-SIAH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-RERE | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-REOR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-REGO | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-REGR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-REAQ | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-ORRE | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-OROR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-ORGO | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GORE | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GOOR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GOGO | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GOGR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GRRE | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GROR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GRGO | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GRGR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-AQRE | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-AQOR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-AQGO | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-AQGR | 20 (40 μL) | 200 μL |
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| PCYT1B-SIAH1-20-AQAQ | 20 (40 μL) | 200 μL |
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SIAH1 Gene Summary
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Siah E3 Ubiquitin Protein Ligase 1
Chromosome: CHR16: 48394453 -48419229
Locus: 16q12.1
PCYT1B Gene Summary
The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: Phosphate Cytidylyltransferase 1, Choline, Beta
Chromosome: CHRX: 24576203 -24690979
Locus: Xp22.11
Gene Diseases
The PCYT1B SIAH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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