PCSK5-DENND1A Fusion FISH Probe
The PCSK5-DENND1A Fusion FISH Probe is used to confirm a fusion of the PCSK5 and DENND1A genes. The fusion of the PCSK5 and DENND1A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCSK5-DENND1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-RERE | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-REOR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-REGO | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-REGR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-REAQ | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-ORRE | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-OROR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-ORGO | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GORE | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GOOR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GOGO | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GOGR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GRRE | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GROR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GRGO | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GRGR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-AQRE | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-AQOR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-AQGO | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-AQGR | 20 (40 μL) | 200 μL |
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| PCSK5-DENND1A-20-AQAQ | 20 (40 μL) | 200 μL |
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PCSK5 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
Gene Name: Proprotein Convertase Subtilisin/kexin Type 5
Chromosome: CHR9: 78505559 -78977255
Locus: 9q21.13
DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
Gene Diseases
The PCSK5 DENND1A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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