PCSK5-DDX58 Fusion FISH Probe
The PCSK5-DDX58 Fusion FISH Probe is used to confirm a fusion of the PCSK5 and DDX58 genes. The fusion of the PCSK5 and DDX58 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCSK5-DDX58-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-RERE | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-REOR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-REGO | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-REGR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-REAQ | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-ORRE | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-OROR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-ORGO | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GORE | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GOOR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GOGO | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GOGR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GRRE | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GROR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GRGO | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GRGR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-AQRE | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-AQOR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-AQGO | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-AQGR | 20 (40 μL) | 200 μL |
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| PCSK5-DDX58-20-AQAQ | 20 (40 μL) | 200 μL |
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PCSK5 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
Gene Name: Proprotein Convertase Subtilisin/kexin Type 5
Chromosome: CHR9: 78505559 -78977255
Locus: 9q21.13
DDX58 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]
Gene Name: DExD/H-box Helicase 58
Chromosome: CHR9: 32455299 -32526322
Locus: 9p21.1
Gene Diseases
The PCSK5 DDX58 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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