PCNT-POC1A Fusion FISH Probe
The PCNT-POC1A Fusion FISH Probe is used to confirm a fusion of the PCNT and POC1A genes. The fusion of the PCNT and POC1A genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCNT-POC1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-RERE | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-REOR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-REGO | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-REGR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-REAQ | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-ORRE | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-OROR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-ORGO | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GORE | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GOOR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GOGO | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GOGR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GRRE | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GROR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GRGO | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GRGR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-AQRE | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-AQOR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-AQGO | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-AQGR | 20 (40 μL) | 200 μL |
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| PCNT-POC1A-20-AQAQ | 20 (40 μL) | 200 μL |
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PCNT Gene Summary
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Pericentrin
Chromosome: CHR21: 47744035 -47865682
Locus: 21q22.3
POC1A Gene Summary
POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome. [provided by RefSeq, Sep 2012]
Gene Name: POC1 Centriolar Protein A
Chromosome: CHR3: 52109248 -52188706
Locus: 3p21.2
Gene Diseases
The PCNT POC1A Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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