PCNT-MCOLN1 Fusion FISH Probe
The PCNT-MCOLN1 Fusion FISH Probe is used to confirm a fusion of the PCNT and MCOLN1 genes. The fusion of the PCNT and MCOLN1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCNT-MCOLN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-RERE | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-REOR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-REGO | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-REGR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-REAQ | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-ORRE | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-OROR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-ORGO | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GORE | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GOOR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GOGO | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GOGR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GRRE | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GROR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GRGO | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GRGR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-AQRE | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-AQOR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-AQGO | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-AQGR | 20 (40 μL) | 200 μL |
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| PCNT-MCOLN1-20-AQAQ | 20 (40 μL) | 200 μL |
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PCNT Gene Summary
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Pericentrin
Chromosome: CHR21: 47744035 -47865682
Locus: 21q22.3
MCOLN1 Gene Summary
This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009]
Gene Name: Mucolipin 1
Chromosome: CHR19: 7587495 -7598895
Locus: 19p13.2
Gene Diseases
The PCNT MCOLN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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