PCMTD1-WRN Fusion FISH Probe
The PCMTD1-WRN Fusion FISH Probe is used to confirm a fusion of the PCMTD1 and WRN genes. The fusion of the PCMTD1 and WRN genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCMTD1-WRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-RERE | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-REOR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-REGO | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-REGR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-REAQ | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-ORRE | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-OROR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-ORGO | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GORE | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GOOR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GOGO | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GOGR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GRRE | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GROR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GRGO | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GRGR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-AQRE | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-AQOR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-AQGO | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-AQGR | 20 (40 μL) | 200 μL |
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| PCMTD1-WRN-20-AQAQ | 20 (40 μL) | 200 μL |
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WRN Gene Summary
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Gene Name: Werner Syndrome RecQ Like Helicase
Chromosome: CHR8: 30890777 -31031277
Locus: 8p12
PCMTD1 Gene Summary
The Protein-L-isoaspartate (D-aspartate) O-methyltransferase Domain Containing 1 (PCMTD1) gene is located on chr8 :52730139-52811735 at 8q11.23.
Gene Name: Protein-L-isoaspartate (D-aspartate) O-methyltransferase Domain Containing 1
Chromosome: CHR8: 52730139 -52811735
Locus: 8q11.23
Gene Diseases
The PCMTD1 WRN Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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