PCDHGC3-QKI Fusion FISH Probe
The PCDHGC3-QKI Fusion FISH Probe is used to confirm a fusion of the PCDHGC3 and QKI genes. The fusion of the PCDHGC3 and QKI genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCDHGC3-QKI-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-RERE | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-REOR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-REGO | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-REGR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-REAQ | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-ORRE | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-OROR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-ORGO | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GORE | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GOOR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GOGO | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GOGR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GRRE | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GROR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GRGO | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GRGR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-AQRE | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-AQOR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-AQGO | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-AQGR | 20 (40 μL) | 200 μL |
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| PCDHGC3-QKI-20-AQAQ | 20 (40 μL) | 200 μL |
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PCDHGC3 Gene Summary
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Name: Protocadherin Gamma Subfamily C, 3
Chromosome: CHR5: 140855568 -140892546
Locus: 5q31.3
QKI Gene Summary
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: QKI, KH Domain Containing RNA Binding
Chromosome: CHR6: 163835674 -163999628
Locus: 6q26
Gene Diseases
The PCDHGC3 QKI Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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