PCDHGA6-JMJD1C Fusion FISH Probe
The PCDHGA6-JMJD1C Fusion FISH Probe is used to confirm a fusion of the PCDHGA6 and JMJD1C genes. The fusion of the PCDHGA6 and JMJD1C genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PCDHGA6-JMJD1C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PCDHGA6-JMJD1C-20-AQAQ | 20 (40 μL) | 200 μL |
|
PCDHGA6 Gene Summary
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Name: Protocadherin Gamma Subfamily A, 6
Chromosome: CHR5: 140753650 -140892546
Locus: 5q31.3
JMJD1C Gene Summary
The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Jumonji Domain Containing 1C
Chromosome: CHR10: 64926987 -65225722
Locus: 10q21.3
Gene Diseases
The PCDHGA6 JMJD1C Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|