PCCA-DIAPH3 Fusion FISH Probe
The PCCA-DIAPH3 Fusion FISH Probe is used to confirm a fusion of the PCCA and DIAPH3 genes. The fusion of the PCCA and DIAPH3 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCCA-DIAPH3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-RERE | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-REOR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-REGO | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-REGR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-REAQ | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-ORRE | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-OROR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-ORGO | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GORE | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GOOR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GOGO | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GOGR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GRRE | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GROR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GRGO | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GRGR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-AQRE | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-AQOR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-AQGO | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-AQGR | 20 (40 μL) | 200 μL |
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| PCCA-DIAPH3-20-AQAQ | 20 (40 μL) | 200 μL |
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PCCA Gene Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Name: Propionyl-CoA Carboxylase Alpha Subunit
Chromosome: CHR13: 100741268 -101182691
Locus: 13q32.3
DIAPH3 Gene Summary
This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Diaphanous Related Formin 3
Chromosome: CHR13: 60239722 -60738119
Locus: 13q21.2
Gene Diseases
The PCCA DIAPH3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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