PCBP2-YWHAE Fusion FISH Probe
The PCBP2-YWHAE Fusion FISH Probe is used to confirm a fusion of the PCBP2 and YWHAE genes. The fusion of the PCBP2 and YWHAE genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCBP2-YWHAE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-RERE | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-REOR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-REGO | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-REGR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-REAQ | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-ORRE | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-OROR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-ORGO | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GORE | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GOOR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GOGO | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GOGR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GRRE | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GROR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GRGO | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GRGR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-AQRE | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-AQOR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-AQGO | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-AQGR | 20 (40 μL) | 200 μL |
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| PCBP2-YWHAE-20-AQAQ | 20 (40 μL) | 200 μL |
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PCBP2 Gene Summary
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
Gene Name: Poly(rC) Binding Protein 2
Chromosome: CHR12: 53845885 -53874946
Locus: 12q13.13
YWHAE Gene Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Epsilon
Chromosome: CHR17: 1247833 -1303556
Locus: 17p13.3
Gene Diseases
The PCBP2 YWHAE Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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