PCBP2-CCT5 Fusion FISH Probe
The PCBP2-CCT5 Fusion FISH Probe is used to confirm a fusion of the PCBP2 and CCT5 genes. The fusion of the PCBP2 and CCT5 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCBP2-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| PCBP2-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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PCBP2 Gene Summary
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
Gene Name: Poly(rC) Binding Protein 2
Chromosome: CHR12: 53845885 -53874946
Locus: 12q13.13
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The PCBP2 CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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