PC-THRSP Fusion FISH Probe
The PC-THRSP Fusion FISH Probe is used to confirm a fusion of the PC and THRSP genes. The fusion of the PC and THRSP genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PC-THRSP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-RERE | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-REOR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-REGO | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-REGR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-REAQ | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-ORRE | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-OROR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-ORGO | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-ORAQ | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GORE | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GOOR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GOGO | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GOGR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GOAQ | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GRRE | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GROR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GRGO | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GRGR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-GRAQ | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-AQRE | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-AQOR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-AQGO | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-AQGR | 20 (40 μL) | 200 μL |
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| PC-THRSP-20-AQAQ | 20 (40 μL) | 200 μL |
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PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
THRSP Gene Summary
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
Gene Name: Thyroid Hormone Responsive
Chromosome: CHR11: 77774906 -77779403
Locus: 11q14.1
Gene Diseases
The PC THRSP Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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