PC-ACTN4 Fusion FISH Probe
The PC-ACTN4 Fusion FISH Probe is used to confirm a fusion of the PC and ACTN4 genes. The fusion of the PC and ACTN4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PC-ACTN4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-RERE | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-REOR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-REGO | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-REGR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-REAQ | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-ORRE | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-OROR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-ORGO | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GORE | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GOOR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GOGO | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GOGR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GRRE | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GROR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GRGO | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GRGR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-AQRE | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-AQOR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-AQGO | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-AQGR | 20 (40 μL) | 200 μL |
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| PC-ACTN4-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTN4 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Gene Name: Actinin Alpha 4
Chromosome: CHR19: 39138266 -39221171
Locus: 19q13.2
PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
Gene Diseases
The PC ACTN4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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