PBX1-RFWD2 Fusion FISH Probe
The PBX1-RFWD2 Fusion FISH Probe is used to confirm a fusion of the PBX1 and RFWD2 genes. The fusion of the PBX1 and RFWD2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PBX1-RFWD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-RERE | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-REOR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-REGO | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-REGR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-REAQ | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-ORRE | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-OROR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-ORGO | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GORE | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GOOR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GOGO | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GOGR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GRRE | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GROR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GRGO | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GRGR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-AQRE | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-AQOR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-AQGO | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-AQGR | 20 (40 μL) | 200 μL |
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| PBX1-RFWD2-20-AQAQ | 20 (40 μL) | 200 μL |
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PBX1 Gene Summary
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Name: PBX Homeobox 1
Chromosome: CHR1: 164528596 -164821060
Locus: 1q23.3
RFWD2 Gene Summary
The Ring Finger And WD Repeat Domain 2 (RFWD2) gene is located on chr1 :175913966-176176370 at 1q25.1-q25.2.
Gene Name: Ring Finger And WD Repeat Domain 2
Chromosome: CHR1: 175913966 -176176370
Locus: 1q25.1-q25.2
Gene Diseases
The PBX1 RFWD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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