PAWR-PPP1R12A Fusion FISH Probe
The PAWR-PPP1R12A Fusion FISH Probe is used to confirm a fusion of the PAWR and PPP1R12A genes. The fusion of the PAWR and PPP1R12A genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAWR-PPP1R12A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-RERE | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-REOR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-REGO | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-REGR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-REAQ | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-ORRE | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-OROR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-ORGO | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GORE | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GOOR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GOGO | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GOGR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GRRE | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GROR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GRGO | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GRGR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-AQRE | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-AQOR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-AQGO | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-AQGR | 20 (40 μL) | 200 μL |
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| PAWR-PPP1R12A-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1R12A Gene Summary
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12A
Chromosome: CHR12: 80167342 -80329235
Locus: 12q21.2-q21.31
PAWR Gene Summary
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
Gene Name: Pro-apoptotic WT1 Regulator
Chromosome: CHR12: 79985744 -80084790
Locus: 12q21.2
Gene Diseases
The PAWR PPP1R12A Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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