PARVB-ATP6V1D Fusion FISH Probe
The PARVB-ATP6V1D Fusion FISH Probe is used to confirm a fusion of the PARVB and ATP6V1D genes. The fusion of the PARVB and ATP6V1D genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PARVB-ATP6V1D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-RERE | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-REOR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-REGO | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-REGR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-REAQ | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-ORRE | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-OROR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-ORGO | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-ORAQ | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GORE | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GOOR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GOGO | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GOGR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GOAQ | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GRRE | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GROR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GRGO | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GRGR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-GRAQ | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-AQRE | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-AQOR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-AQGO | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-AQGR | 20 (40 μL) | 200 μL |
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| PARVB-ATP6V1D-20-AQAQ | 20 (40 μL) | 200 μL |
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PARVB Gene Summary
This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Parvin Beta
Chromosome: CHR22: 44395090 -44565112
Locus: 22q13.31
ATP6V1D Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V1 Subunit D
Chromosome: CHR14: 67804580 -67826720
Locus: 14q23.3
Gene Diseases
The PARVB ATP6V1D Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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