PARN-ABCA3 Fusion FISH Probe
The PARN-ABCA3 Fusion FISH Probe is used to confirm a fusion of the PARN and ABCA3 genes. The fusion of the PARN and ABCA3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PARN-ABCA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-RERE | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-REOR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-REGO | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-REGR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-REAQ | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-ORRE | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-OROR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-ORGO | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GORE | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GOOR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GOGO | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GOGR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GRRE | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GROR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GRGO | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GRGR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-AQRE | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-AQOR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-AQGO | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-AQGR | 20 (40 μL) | 200 μL |
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| PARN-ABCA3-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCA3 Gene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]
Gene Name: ATP Binding Cassette Subfamily A Member 3
Chromosome: CHR16: 2325878 -2390747
Locus: 16p13.3
PARN Gene Summary
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Poly(A)-specific Ribonuclease
Chromosome: CHR16: 14529556 -14724128
Locus: 16p13.12
Gene Diseases
The PARN ABCA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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