PARL-ABCC5 Fusion FISH Probe
The PARL-ABCC5 Fusion FISH Probe is used to confirm a fusion of the PARL and ABCC5 genes. The fusion of the PARL and ABCC5 genes has been associated with Head And Neck Squamous Cell Carcinoma , and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PARL-ABCC5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-RERE | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-REOR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-REGO | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-REGR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-REAQ | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-ORRE | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-OROR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-ORGO | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GORE | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GOOR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GOGO | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GOGR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GRRE | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GROR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GRGO | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GRGR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-AQRE | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-AQOR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-AQGO | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-AQGR | 20 (40 μL) | 200 μL |
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| PARL-ABCC5-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCC5 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: ATP Binding Cassette Subfamily C Member 5
Chromosome: CHR3: 183637723 -183735727
Locus: 3q27.1
PARL Gene Summary
This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]
Gene Name: Presenilin Associated Rhomboid Like
Chromosome: CHR3: 183547172 -183602693
Locus: 3q27.1
Gene Diseases
The PARL ABCC5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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