PARD6B-PTPN1 Fusion FISH Probe
The PARD6B-PTPN1 Fusion FISH Probe is used to confirm a fusion of the PARD6B and PTPN1 genes. The fusion of the PARD6B and PTPN1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PARD6B-PTPN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-RERE | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-REOR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-REGO | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-REGR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-REAQ | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-ORRE | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-OROR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-ORGO | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GORE | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GOOR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GOGO | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GOGR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GRRE | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GROR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GRGO | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GRGR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-AQRE | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-AQOR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-AQGO | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-AQGR | 20 (40 μL) | 200 μL |
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| PARD6B-PTPN1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN1 Gene Summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 1
Chromosome: CHR20: 49126890 -49201086
Locus: 20q13.13
PARD6B Gene Summary
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Par-6 Family Cell Polarity Regulator Beta
Chromosome: CHR20: 49348080 -49370278
Locus: 20q13.13
Gene Diseases
The PARD6B PTPN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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