PARD3-NRXN1 Fusion FISH Probe
The PARD3-NRXN1 Fusion FISH Probe is used to confirm a fusion of the PARD3 and NRXN1 genes. The fusion of the PARD3 and NRXN1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PARD3-NRXN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-RERE | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-REOR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-REGO | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-REGR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-REAQ | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-ORRE | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-OROR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-ORGO | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GORE | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GOOR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GOGO | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GOGR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GRRE | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GROR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GRGO | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GRGR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-AQRE | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-AQOR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-AQGO | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-AQGR | 20 (40 μL) | 200 μL |
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| PARD3-NRXN1-20-AQAQ | 20 (40 μL) | 200 μL |
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NRXN1 Gene Summary
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
Gene Name: Neurexin 1
Chromosome: CHR2: 50145642 -51259674
Locus: 2p16.3
PARD3 Gene Summary
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Par-3 Family Cell Polarity Regulator
Chromosome: CHR10: 34398487 -35104253
Locus: 10p11.22-p11.21
Gene Diseases
The PARD3 NRXN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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