PARD3-ARMC4 Fusion FISH Probe
The PARD3-ARMC4 Fusion FISH Probe is used to confirm a fusion of the PARD3 and ARMC4 genes. The fusion of the PARD3 and ARMC4 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PARD3-ARMC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-RERE | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-REOR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-REGO | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-REGR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-REAQ | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-ORRE | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-OROR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-ORGO | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GORE | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GOOR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GOGO | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GOGR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GRRE | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GROR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GRGO | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GRGR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-AQRE | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-AQOR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-AQGO | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-AQGR | 20 (40 μL) | 200 μL |
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| PARD3-ARMC4-20-AQAQ | 20 (40 μL) | 200 μL |
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ARMC4 Gene Summary
The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Name: Armadillo Repeat Containing 4
Chromosome: CHR10: 28101096 -28287977
Locus: 10p12.1
PARD3 Gene Summary
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Par-3 Family Cell Polarity Regulator
Chromosome: CHR10: 34398487 -35104253
Locus: 10p11.22-p11.21
Gene Diseases
The PARD3 ARMC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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