PANK1-PDK3 Fusion FISH Probe
The PANK1-PDK3 Fusion FISH Probe is used to confirm a fusion of the PANK1 and PDK3 genes. The fusion of the PANK1 and PDK3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PANK1-PDK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-RERE | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-REOR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-REGO | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-REGR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-REAQ | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-ORRE | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-OROR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-ORGO | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GORE | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GOOR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GOGO | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GOGR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GRRE | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GROR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GRGO | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GRGR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-AQRE | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-AQOR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-AQGO | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-AQGR | 20 (40 μL) | 200 μL |
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| PANK1-PDK3-20-AQAQ | 20 (40 μL) | 200 μL |
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PDK3 Gene Summary
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Name: Pyruvate Dehydrogenase Kinase 3
Chromosome: CHRX: 24483343 -24568583
Locus: Xp22.11
PANK1 Gene Summary
This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]
Gene Name: Pantothenate Kinase 1
Chromosome: CHR10: 91339253 -91405329
Locus: 10q23.31
Gene Diseases
The PANK1 PDK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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