PAN3-FLT3 Fusion FISH Probe
The PAN3-FLT3 Fusion FISH Probe is used to confirm a fusion of the PAN3 and FLT3 genes. The fusion of the PAN3 and FLT3 genes has been associated with Colon Adenocarcinoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAN3-FLT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-RERE | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-REOR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-REGO | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-REGR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-REAQ | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-ORRE | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-OROR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-ORGO | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GORE | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GOOR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GOGO | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GOGR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GRRE | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GROR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GRGO | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GRGR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-AQRE | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-AQOR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-AQGO | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-AQGR | 20 (40 μL) | 200 μL |
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| PAN3-FLT3-20-AQAQ | 20 (40 μL) | 200 μL |
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FLT3 Gene Summary
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Gene Name: Fms Related Tyrosine Kinase 3
Chromosome: CHR13: 28577410 -28674729
Locus: 13q12.2
PAN3 Gene Summary
The PAN3 Poly(A) Specific Ribonuclease Subunit (PAN3) gene is located on chr13 :28712642-28869475 at 13q12.2.
Gene Name: PAN3 Poly(A) Specific Ribonuclease Subunit
Chromosome: CHR13: 28712642 -28869475
Locus: 13q12.2
Gene Diseases
The PAN3 FLT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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