PAK4-SPINT2 Fusion FISH Probe
The PAK4-SPINT2 Fusion FISH Probe is used to confirm a fusion of the PAK4 and SPINT2 genes. The fusion of the PAK4 and SPINT2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAK4-SPINT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-RERE | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-REOR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-REGO | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-REGR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-REAQ | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-ORRE | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-OROR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-ORGO | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GORE | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GOOR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GOGO | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GOGR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GRRE | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GROR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GRGO | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GRGR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-AQRE | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-AQOR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-AQGO | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-AQGR | 20 (40 μL) | 200 μL |
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| PAK4-SPINT2-20-AQAQ | 20 (40 μL) | 200 μL |
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PAK4 Gene Summary
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: P21 (RAC1) Activated Kinase 4
Chromosome: CHR19: 39616419 -39670046
Locus: 19q13.2
SPINT2 Gene Summary
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: Serine Peptidase Inhibitor, Kunitz Type 2
Chromosome: CHR19: 38755097 -38783254
Locus: 19q13.2
Gene Diseases
The PAK4 SPINT2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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