PAK4-RPGR Fusion FISH Probe
The PAK4-RPGR Fusion FISH Probe is used to confirm a fusion of the PAK4 and RPGR genes. The fusion of the PAK4 and RPGR genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAK4-RPGR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-RERE | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-REOR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-REGO | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-REGR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-REAQ | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-ORRE | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-OROR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-ORGO | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GORE | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GOOR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GOGO | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GOGR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GRRE | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GROR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GRGO | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GRGR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-AQRE | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-AQOR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-AQGO | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-AQGR | 20 (40 μL) | 200 μL |
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| PAK4-RPGR-20-AQAQ | 20 (40 μL) | 200 μL |
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RPGR Gene Summary
This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. [provided by RefSeq, Dec 2008]
Gene Name: Retinitis Pigmentosa GTPase Regulator
Chromosome: CHRX: 38128422 -38186788
Locus: Xp11.4
PAK4 Gene Summary
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: P21 (RAC1) Activated Kinase 4
Chromosome: CHR19: 39616419 -39670046
Locus: 19q13.2
Gene Diseases
The PAK4 RPGR Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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